VIPS: VASCULAR EFFECTS OF INFECTION IN PEDIATRIC STROKE STUDY

The VIPS I study established a network of 37 sites on 5 continents, enrolled 355 children with arterial ischemic stroke (AIS) and 354 stroke-free controls, and generated a wealth of new knowledge on the relationship between infection and childhood AIS. The goals of the VIPS II study are to (1) identify known and novel pathogens in children with AIS and determine whether different pathogens are associated with stroke subtypes; (2) determine whether children with arteriopathic AIS have a distinct analyte signature consistent with an alternative pathway of inflammation compared to children with cardioembolic or idiopathic stroke; and (3) obtain and analyze the childhood stroke transcriptome and identify molecular correlates of stroke heterogeneity.  

Location: International multisite study

BALANCE Investigators: Heather Fullerton, MD, MAS